Description

tert-Butyl 4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indazole-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected indazole core and a pinacol boronate ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions for the synthesis of complex, drug-like molecules. It is primarily needed by research and development teams in the pharmaceutical and biotechnology industries for the discovery and development of new therapeutic agents, particularly in oncology and CNS drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group serves as a versatile handle for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize lead compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: A valuable building block for constructing heterobifunctional molecules used in targeted protein degradation.
• Chemical Biology Research: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical development pipelines.

Basic Information

Product Name	tert-Butyl 4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indazole-1-Carboxylate
CAS No.	1446443-06-6
Molecular Formula	C₁₈H₂₅BN₂O₄
Molecular Weight	344.22 g/mol
Synonyms	1-Boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylic acid tert-butyl ester; 1H-Indazole-1-carboxylic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 4-BPin-1-Boc-indazole; 1-Boc-4-BPin-indazole; 1446443-06-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indazole-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.