Description

1-((3-Bromo-4-Fluorophenyl)Sulfonyl)Piperidin-4-Ol CAS NO 1446237-72-4 is a high-purity, advanced pharmaceutical intermediate characterized by its sulfonyl piperidine core and halogenated aromatic ring. This compound is of significant value for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, where precise chemical structure and reliable purity are paramount.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis Building Block: Used in organic synthesis to introduce the (3-bromo-4-fluorophenyl)sulfonyl piperidin-4-ol moiety into more complex molecular architectures.
• Protease Inhibitor Development: Potential application in the design and synthesis of protease inhibitors due to the sulfonamide functional group.
• Kinase Inhibitor Synthesis: A valuable intermediate for creating potential kinase inhibitors, a major class of targeted cancer therapies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-((3-Bromo-4-Fluorophenyl)Sulfonyl)Piperidin-4-Ol
CAS No.	1446237-72-4
Molecular Formula	C11H13BrFNO3S
Molecular Weight	362.19 g/mol
Synonyms	4-Piperidinol, 1-[(3-bromo-4-fluorophenyl)sulfonyl]-; 1-(3-Bromo-4-fluorobenzenesulfonyl)piperidin-4-ol; 4-Hydroxy-1-(3-bromo-4-fluorophenylsulfonyl)piperidine; 1-(3-Bromo-4-fluorophenylsulfonyl)-4-hydroxypiperidine; 1-(3-Bromo-4-fluoro-benzenesulfonyl)-piperidin-4-ol; 1-[(3-Bromo-4-fluorophenyl)sulfonyl]-4-piperidinol; (3-Bromo-4-fluorophenyl)(4-hydroxypiperidin-1-yl)sulfone
EINECS	Contact for details

Quality Control

Our 1-((3-Bromo-4-Fluorophenyl)Sulfonyl)Piperidin-4-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing specific batch results are available upon request, providing full traceability and compliance data for your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.