Description

Methanesulfonato2-Di-T-Butylphosphino-2'-(N,n-Dimethylamino)Biphenyl)(2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(II) is a highly specialized, air-sensitive palladium catalyst complex, recognized for its superior performance in demanding cross-coupling reactions. Its value lies in the unique combination of the Buchwald-type biarylphosphine ligand and the methanesulfonate anion, which provides excellent activity and stability for synthesizing complex pharmaceutical intermediates and fine chemicals. This product is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity catalysts to drive innovation in small molecule synthesis.

Application

This palladium catalyst is engineered for precision in organic synthesis, particularly where traditional catalysts fall short. Its primary and related applications include:

• Buchwald-Hartwig Amination: A premier catalyst for C-N bond formation between aryl halides and amines, crucial for constructing nitrogen-containing heterocycles in drug discovery.
• Suzuki-Miyaura Cross-Coupling: Facilitates efficient C-C bond formation between aryl/heteroaryl boronic acids and halides for building biaryl scaffolds.
• Pharmaceutical Intermediate Synthesis: Key for manufacturing active pharmaceutical ingredients (APIs) and complex, high-value intermediates under mild conditions.
• Agrochemical Compound Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring selective coupling steps.
• Material Science Research: Enables the synthesis of conjugated polymers and organic electronic materials through efficient cross-coupling.
• Process Chemistry & Scale-Up: Valued for its consistent performance and robustness in moving reactions from laboratory to pilot and production scale.

Basic Information

Product Name	Methanesulfonato2-Di-T-Butylphosphino-2'-(N,n-Dimethylamino)Biphenyl)(2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(II)
CAS No.	1445085-92-6
Molecular Formula	C35H45N2O3PPdS
Molecular Weight	~711.18 g/mol
Synonyms	Palladium Methanesulfonate Buchwald Catalyst; [2'-(Dimethylamino)-2-biphenylyl]di-tert-butylphosphine](2'-amino-1,1'-biphenyl-2-yl)palladium(II) methanesulfonate; Pd-118 Methanesulfonate; BrettPhos Pd G3 Methanesulfonate; (2-Di-tert-butylphosphino-2'-(N,N-dimethylamino)biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) methanesulfonate; Palladium(II) methanesulfonate complex with BrettPhos; Pd(BrettPhos)(2-aminobiphenyl) methanesulfonate; CAS 1445085-92-6.
EINECS	Contact for details

Quality Control

Every batch of our palladium catalyst is produced and tested to meet the exacting standards required for catalytic synthesis and pharmaceutical applications. We employ advanced analytical techniques including NMR, HPLC, and ICP-MS to verify identity, purity, and low levels of residual metals. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for assay, ligand content, and impurity profiles. Our quality system is designed to ensure reproducible performance and supply chain reliability for our global partners.

Storage

Preserve in a tightly closed container, protected from light. This material is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange-brown solid
Identification (IR)	Conforms to structure
Assay (Pd Content)	≥ 14.5% (by ICP-MS)
Purity (HPLC)	≥ 95.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals (ICP-MS)	< 100 ppm total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.