Description

3-(Fluoromethyl)Azetidine is a high-value, nitrogen-containing heterocyclic building block featuring a reactive fluoromethyl substituent. This unique structure makes it a critical intermediate for the synthesis of novel pharmacologically active compounds, particularly in medicinal chemistry and agrochemical research. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce fluorine-containing motifs to modulate the properties of target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of central nervous system (CNS) and antiviral drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands and organocatalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and electronic materials that require fluorinated heterocyclic components.
• PET (Positron Emission Tomography) Tracer Precursor: Potential use in the synthesis of fluorine-18 labeled compounds for medical imaging diagnostics.
• Chemical Biology Probes: Useful for creating fluorinated probes and tags to study biological systems and protein interactions.

Basic Information

Product Name	3-(Fluoromethyl)Azetidine
CAS No.	1443983-83-2
Molecular Formula	C4H8FN
Molecular Weight	89.11 g/mol
Synonyms	3-(Fluoromethyl)azetidine; Azetidine, 3-(fluoromethyl)-; 3-Fluoromethylazetidine; 1-Azabicyclo[1.1.0]butane, 3-(fluoromethyl)-; (Azetidin-3-yl)methanol, 3-fluoro-; Fluoromethylazetidine; 3-Fluoroazetidinemethane
EINECS	Contact for details

Quality Control

Our 3-(Fluoromethyl)Azetidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.