Description

4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline-1,3-Dione (CAS NO 1443981-83-6) is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which serves as a versatile precursor for constructing complex pharmacophores and functional materials. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the difluoro moiety can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for advanced organic materials, including polymers and liquid crystals, where fluorine incorporation can modify electronic properties and stability.
• Chemical Biology Probe Development: Employed in the synthesis of labeled compounds and molecular probes for studying biological mechanisms and enzyme interactions.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis, including fluorination reactions and heterocycle formation.

Basic Information

Product Name	4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline-1,3-Dione
CAS No.	1443981-83-6
Molecular Formula	C9H5F2NO2
Molecular Weight	197.14 g/mol
Synonyms	4,4-Difluoro-1,2,3,4-tetrahydroisoquinoline-1,3-dione; 4,4-Difluoro-1H-isoindole-1,3(2H)-dione; 4,4-Difluoroisoindoline-1,3-dione; 4,4-Difluoro-2,3-dihydro-1H-isoindole-1,3-dione; 1,3-Dioxo-4,4-difluoro-1,2,3,4-tetrahydroisoquinoline; 4,4-Difluorotetrahydroisoquinolinedione
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.