Description

2-Fluoro-n-(2-Hydroxyethyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is a high-value, advanced pharmaceutical intermediate featuring a benzamide core functionalized with both a boronic ester pinacol group and a fluoro substituent. This compound is critical for enabling modern synthetic strategies, particularly Suzuki-Miyaura cross-coupling reactions, which are fundamental to constructing complex molecules in drug discovery. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: The tetramethyl-1,3,2-dioxaborolan-2-yl (pinacol boronic ester) group makes it an essential reagent for forming carbon-carbon bonds under mild conditions, a cornerstone of modern medicinal chemistry.
• Agrochemical Research: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluorine atom and boronic ester moiety can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands or catalysts used in asymmetric synthesis and other transition metal-catalyzed processes.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials, such as those used in OLEDs or sensors, where precise molecular architecture is required.
• Chemical Biology Probe Synthesis: Employed in the creation of molecular probes for studying biological pathways and protein functions.

Basic Information

Product Name	2-Fluoro-n-(2-Hydroxyethyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide
CAS No.	1443442-75-8
Molecular Formula	C15H21BFNO4
Molecular Weight	309.14 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-N-(2-hydroxyethyl)benzamide; 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2-hydroxyethyl)benzamide; N-(2-Hydroxyethyl)-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 2-Fluoro-4-pinacolatoboron-N-(2-hydroxyethyl)benzamide; CAS 1443442-75-8; Boronic acid, B-[2-fluoro-4-[[(2-hydroxyethyl)amino]carbonyl]phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; Pinacol 2-fluoro-4-[(2-hydroxyethyl)carbamoyl]phenylboronate
EINECS	Contact for details

Quality Control

Our 2-Fluoro-n-(2-Hydroxyethyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.