Description

2,3-Difluoro-4-Piperidinophenylboronic Acid is a high-value boronic acid derivative and a key building block in modern synthetic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, due to the presence of the piperidine moiety.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific fluorinated aromatic scaffolds.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and semiconductors, where fluorination enhances stability and performance.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and enzyme inhibitors for biochemical research and diagnostic applications.
• Catalyst Ligand Development: The boronic acid and amine functional groups make it a candidate for designing novel ligands in transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital component for custom synthesis houses serving the life sciences sector, enabling the production of bespoke, complex molecules.

Basic Information

Product Name	2,3-Difluoro-4-Piperidinophenylboronic Acid
CAS No.	1443380-15-1
Molecular Formula	C11H14BF2NO2
Molecular Weight	237.05 g/mol
Synonyms	(2,3-Difluoro-4-piperidin-1-ylphenyl)boronic acid; 4-Piperidino-2,3-difluorophenylboronic acid; 2,3-Difluoro-4-(1-piperidinyl)benzeneboronic acid; 2,3-Difluoro-4-piperidin-1-ylbenzeneboronic acid; Boronic acid, B-(2,3-difluoro-4-(1-piperidinyl)phenyl)-; 1443380-15-1; 2,3-Difluoro-4-piperidinophenylboronic Acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Every batch of 2,3-Difluoro-4-Piperidinophenylboronic Acid is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the container under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light may affect purity and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.