Description

[(3-Bromocyclobutoxy)Methyl]Benzene is a specialized brominated cyclobutane derivative, a high-value building block in advanced organic synthesis. Its unique structure, featuring a bromine atom on a strained cyclobutyl ring adjacent to a benzyloxy group, makes it a critical intermediate for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical sectors, where it is used to introduce the cyclobutyl moiety and facilitate further functionalization via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, where the cyclobutyl ring can enhance biological activity and environmental profile.
• Ligand and Catalyst Development: Acts as a scaffold for creating sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of monomers for advanced polymers with specific thermal or optical properties.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study enzyme function and cellular pathways.
• Cross-Coupling Reactions: The bromine atom is an effective handle for Suzuki, Negishi, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.

Basic Information

Product Name	[(3-Bromocyclobutoxy)Methyl]Benzene
CAS No.	1443110-01-7
Molecular Formula	C11H13BrO
Molecular Weight	241.13 g/mol
Synonyms	Benzyl 3-Bromocyclobutyl Ether; (3-Bromocyclobutyloxymethyl)benzene; 1-[(3-Bromocyclobutoxy)methyl]benzene; 3-Bromocyclobutyl Benzyl Ether; α-[(3-Bromocyclobutoxy)methyl]toluene; (3-Bromocyclobutyl)methyl Phenyl Ether; Benzyl (3-Bromocyclobutyl) Ether
EINECS	Contact for details

Quality Control

Our [(3-Bromocyclobutoxy)Methyl]Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.