Description

2H-1-Benzopyran-3-Carboxylic Acid, 2-Oxo-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, advanced pharmaceutical intermediate featuring a benzopyran core functionalized with a pinacol boronate ester. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions to construct complex bioactive molecules. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel drug candidates and functional compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Essential boron reagent for forming carbon-carbon bonds in complex molecule assembly, a cornerstone of modern drug discovery.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Agrochemical Synthesis: Building block for creating novel pesticides and herbicides with enhanced efficacy.
• Material Science: Potential monomer or precursor for organic electronic materials and functional polymers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug development pipelines.

Basic Information

Product Name	2H-1-Benzopyran-3-Carboxylic Acid, 2-Oxo-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1442461-73-5
Molecular Formula	C16H19BO6
Molecular Weight	318.13 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-oxo-2H-chromene-3-carboxylic acid; 2-Oxo-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-chromene-3-carboxylic acid; 7-BPin-2-oxo-2H-chromene-3-carboxylic acid; 2-Oxo-7-(pinacolatoboron)-2H-chromene-3-carboxylic acid; Coumarin-3-carboxylic acid-7-boronic acid pinacol ester; 1442461-73-5; 7-Boronopinacolate-2-oxo-2H-chromene-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2H-1-Benzopyran-3-Carboxylic Acid, 2-Oxo-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.