Description

2-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Propan-2-Ol Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester group, making it a critical building block for modern medicinal chemistry. Its core value lies in enabling efficient, high-yield Suzuki-Miyaura cross-coupling reactions, which are fundamental for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel small-molecule therapeutics, including kinase inhibitors and other targeted agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, neurology, and antiviral therapies.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between the pyridine-boronate moiety and various aryl/heteroaryl halides under palladium catalysis.
• Kinase Inhibitor Development: Used in the construction of heterocyclic cores commonly found in protein kinase inhibitor candidates.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Material Science: Potential monomer or precursor for organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized in the synthesis of bifunctional molecules for targeted protein degradation.

Basic Information

Product Name	2-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Propan-2-Ol Hydrochloride
CAS No.	1441765-57-6
Molecular Formula	C14H23BClNO3
Molecular Weight	299.60 g/mol
Synonyms	2-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)propan-2-ol hydrochloride; 2-Propan-2-ol, 2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-, hydrochloride; 2-(5-(Pinacolatoboryl)pyridin-2-yl)propan-2-ol hydrochloride; 2-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)-2-propanol hydrochloride; 2-(5-Boronic acid pinacol ester-pyridin-2-yl)isopropanol hydrochloride; 2-(2-Pyridyl)isopropyl alcohol-5-boronic acid pinacol ester hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Propan-2-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.