Description

4-{[4-(Hydroxymethyl)Phenyl]Amino}-4-Oxobut-2-Enoic Acid is a specialized organic compound featuring a maleamic acid core linked to a hydroxymethylphenyl group, making it a valuable multifunctional building block for advanced synthesis. This compound matters for its ability to introduce both a reactive double bond and a protected hydroxyl functionality into target molecules, enabling the creation of complex polymers, linkers, and pharmaceutical intermediates. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel drug candidates, particularly for creating amide-linked prodrugs or targeted delivery systems.
• Polymer Chemistry: Acts as a functional monomer or cross-linking agent for synthesizing specialty polymers with tailored properties like pH-responsiveness or biodegradability.
• Bioconjugation & Linker Synthesis: Utilized in the design of chemical linkers for antibody-drug conjugates (ADCs) or other bioconjugation strategies, leveraging its reactive maleimide-like moiety.
• Agrochemical Research: Employed in the synthesis of new active ingredients for crop protection, where its structural motifs can contribute to herbicidal or fungicidal activity.
• Material Science: Used in the development of advanced coatings, adhesives, or resins that require specific chemical functionality for performance enhancement.
• Chemical Biology Probes: Functions as a scaffold for creating probes that can selectively label or interact with biological targets in research settings.

Basic Information

Product Name	4-{[4-(Hydroxymethyl)Phenyl]Amino}-4-Oxobut-2-Enoic Acid
CAS No.	1440537-87-0
Molecular Formula	C11H11NO4
Molecular Weight	221.21 g/mol
Synonyms	4-[(4-Hydroxymethylphenyl)amino]-4-oxobut-2-enoic acid; (2E)-4-[(4-Hydroxymethylphenyl)amino]-4-oxo-2-butenoic acid; N-(4-Hydroxymethylphenyl)maleamic acid; Maleamic acid, N-(4-hydroxymethylphenyl)-; 4-Oxo-4-[(4-(hydroxymethyl)phenyl)amino]but-2-enoic acid
EINECS	Contact for details

Quality Control

Our 4-{[4-(Hydroxymethyl)Phenyl]Amino}-4-Oxobut-2-Enoic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, related substances, and other critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.