Description

2-(Tetrahydro-Pyran-2-Yl)-5-Trifluoromethyl-2H-Pyrazole-3-Carbaldehyde is a high-value, multi-functional heterocyclic building block containing both pyrazole and tetrahydropyran moieties. This compound is essential for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals due to its reactive aldehyde group and trifluoromethyl substitution. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating novel pyrazole-based ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of advanced organic materials, including liquid crystals and organic semiconductors, due to its rigid heterocyclic structure.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(Tetrahydro-Pyran-2-Yl)-5-Trifluoromethyl-2H-Pyrazole-3-Carbaldehyde
CAS No.	1437794-28-9
Molecular Formula	C10H11F3N2O2
Molecular Weight	248.20 g/mol
Synonyms	5-(Trifluoromethyl)-2-(tetrahydro-2H-pyran-2-yl)-2H-pyrazole-3-carbaldehyde; 2H-Pyrazole-3-carbaldehyde, 2-(tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-; 2-(Oxan-2-yl)-5-(trifluoromethyl)pyrazole-3-carbaldehyde; 2-(Tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-2H-pyrazole-3-carboxaldehyde; TPTC; THP-protected trifluoromethyl pyrazole carbaldehyde
EINECS	Contact for details

Quality Control

Every batch of 2-(Tetrahydro-Pyran-2-Yl)-5-Trifluoromethyl-2H-Pyrazole-3-Carbaldehyde is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.