Description

2-(2-Fluoro-4-(Methylthio)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for pharmaceutical and advanced material synthesis. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated and aryl sulfide motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, such as those used in OLEDs and semiconductors.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a boron reagent for palladium-catalyzed cross-coupling with organic halides to form biaryl and heterobiaryl compounds.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes and tool compounds for target identification and validation.
• Ligand and Catalyst Development: Used as a starting material for synthesizing novel ligands and organometallic catalysts.

Basic Information

Product Name	2-(2-Fluoro-4-(Methylthio)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1436431-16-1
Molecular Formula	C13H18BFO2S
Molecular Weight	268.16 g/mol
Synonyms	2-Fluoro-4-(methylthio)benzeneboronic acid pinacol ester; 2-Fluoro-4-methylsulfanylbenzeneboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[2-fluoro-4-(methylthio)phenyl]-1,3,2-dioxaborolane; (2-Fluoro-4-(methylthio)phenyl)boronic acid pinacol ester; Pinacol (2-Fluoro-4-(methylthio)phenyl)boronate; 2-(2-Fluoro-4-(Methylmercapto)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(2-Fluoro-4-(Methylthio)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for every lot and provided upon request, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.