Description

(R)-2,2',3,3'-Tetrahydro-6,6'-Bis[4-(Trifluoromethyl)Phenyl]-1,1'-Spirobi[1H-Indene]-7,7'-Diol is a high-value, chiral spirobiindane derivative, a key structural motif in advanced organic synthesis. Its significance lies in its role as a sophisticated ligand or building block for asymmetric catalysis and the development of novel pharmaceuticals and functional materials. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries, particularly those focused on creating enantiomerically pure substances.

Application

• As a chiral ligand or catalyst precursor in asymmetric synthesis, including hydrogenation, C-C bond formation, and other transition metal-catalyzed reactions.
• As a key synthetic intermediate in the research and development of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or metabolic disorder targets.
• In the development of advanced materials, such as chiral polymers, liquid crystals, or molecular recognition systems.
• For methodology development in academic and industrial R&D labs exploring new catalytic cycles and stereoselective transformations.
• As a reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Potential use in agrochemical research for the synthesis of enantiomerically pure herbicides or fungicides.

Basic Information

Product Name	(R)-2,2',3,3'-Tetrahydro-6,6'-Bis[4-(Trifluoromethyl)Phenyl]-1,1'-Spirobi[1H-Indene]-7,7'-Diol
CAS No.	1435948-34-7
Molecular Formula	C35H24F6O2
Molecular Weight	590.56 g/mol
Synonyms	(R)-6,6'-Bis[4-(trifluoromethyl)phenyl]-1,1'-spirobi[1H-indene]-7,7'-diol; (R)-SPIROL; (R)-Spirobiindane-7,7'-diol derivative; (R)-2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol, 6,6'-bis[4-(trifluoromethyl)phenyl]-; (R)-BINOL analog; Chiral spiro diol ligand; (R)-TFM-Spirobiindanediol
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is fully characterized using techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC assay), enantiomeric excess (ee), and impurity profile is provided with every shipment. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. The material is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.