Description

2-Fluoro-4-(Pentafluorosulfur)-Dl-Phenylalanine is a specialized fluorinated amino acid derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, incorporating both fluorine and a pentafluorosulfur (SF5) group, makes it a high-value intermediate for modulating the physicochemical properties of target molecules. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where its introduction can significantly enhance metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the SF5 and fluorine groups can improve biological activity and environmental persistence profiles.
• Peptidomimetics & Bioactive Peptides: Incorporated into peptide backbones to create analogs with enhanced stability against enzymatic degradation and improved membrane permeability.
• Material Science Precursor: Serves as a functional monomer or cross-linking agent in the development of specialty polymers and advanced materials with unique surface properties.
• Chemical Biology Probe: Utilized as a tagged amino acid in activity-based protein profiling (ABPP) and other biochemical assays to study enzyme function and mechanism.
• Radiopharmaceutical Labeling: The fluorine atom provides a potential site for isotopic labeling (e.g., with 18F) for use in Positron Emission Tomography (PET) imaging agent development.

Basic Information

Product Name	2-Fluoro-4-(Pentafluorosulfur)-Dl-Phenylalanine
CAS No.	1435806-16-8
Molecular Formula	C9H7F6NO2S
Molecular Weight	307.21 g/mol
Synonyms	DL-2-Fluoro-4-(pentafluoro-λ6-sulfanyl)phenylalanine; 4-(Pentafluorosulfanyl)-2-fluorophenylalanine; 2-Fluoro-4-(SF5)-DL-phenylalanine; (RS)-2-Amino-3-[2-fluoro-4-(pentafluoro-λ6-sulfanyl)phenyl]propanoic acid; F-SF5-Phe-OH; SF5-Phenylalanine derivative; 2-F-4-SF5-DL-Phe
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(Pentafluorosulfur)-Dl-Phenylalanine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and specific tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with your research or cGMP starting material requirements. Specifications can be tailored to meet the needs of advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.