Description

[1,3-Bis[2,6-Bis(1-Ethylpropyl)Phenyl]-4,5-Dichloro-Imidazol-2-Ylidene]-Dichloro-(3-Chloropyridin-1-Ium-1-Yl)Palladium is a highly specialized, third-generation N-heterocyclic carbene (NHC) palladium precatalyst designed for demanding cross-coupling reactions. Its value lies in exceptional air and moisture stability, combined with high catalytic activity at low loadings, which significantly improves process reliability and yield in fine chemical synthesis. This advanced catalyst is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors developing complex organic molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key catalyst for constructing complex carbon-carbon and carbon-heteroatom bonds in active pharmaceutical ingredients (APIs), particularly for Suzuki-Miyaura, Buchwald-Hartwig, and Negishi cross-couplings.
• Agrochemical Manufacturing: Used in the synthesis of novel herbicides, fungicides, and insecticides that require the formation of biaryl and aryl-heteroaryl structures.
• Materials Science R&D: Enables the synthesis of conjugated polymers, organic semiconductors, and liquid crystals for electronic and optoelectronic devices.
• Academic & Industrial Research: A preferred precatalyst for method development and exploring new catalytic transformations due to its robustness and predictable performance.
• Scale-up Process Development: Ideal for transitioning from laboratory-scale discovery to pilot plant and commercial manufacturing, offering improved handling and consistent results.

Basic Information

Item	Details
Product Name	[1,3-Bis[2,6-Bis(1-Ethylpropyl)Phenyl]-4,5-Dichloro-Imidazol-2-Ylidene]-Dichloro-(3-Chloropyridin-1-Ium-1-Yl)Palladium
CAS No.	1435347-24-2
Molecular Formula	C43H55Cl5N3Pd
Molecular Weight	902.99 g/mol
Synonyms	PEPPSI-IPent(Cl) Pd Precatalyst; Dichloro[1,3-bis[2,6-bis(1-ethylpropyl)phenyl]-4,5-dichloro-2-imidazolylidene](3-chloropyridine)palladium(II); Third-Generation PEPPSI Catalyst; Pd-PEPPSI-IPent(Cl); NHC-Pd(II) Complex; Air-Stable Pd Precatalyst; (SIPr)Pd(3-Cl-py)Cl2 (analogous structure); Palladium N-Heterocyclic Carbene Complex
EINECS	Contact for details

Quality Control

Every batch of our palladium precatalyst is manufactured and analyzed under strict quality control protocols to ensure high purity and consistent catalytic performance. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing key parameters such as palladium content, purity by NMR and HPLC, and residual solvent levels. Our production adheres to cGMP guidelines where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cool environment. This compound is moisture-sensitive and easily oxidized; prolonged exposure to air and ambient humidity should be avoided to maintain catalytic activity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Palladium (Pd) Content	11.5 - 12.5 %
Solvent Residue (GC)	Meet ICH guidelines
Water Content (KF)	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.