Description

5-(4-Methoxybenzyloxy)-2-Ethynyl-1,3-Difluorobenzene is a high-value, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound matters for its unique molecular architecture, combining a difluorobenzene core with an ethynyl group and a methoxybenzyloxy side chain, enabling precise structural modifications in complex molecule synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Key pharmaceutical intermediate in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Precursor for the development of agrochemicals, including novel herbicides and fungicides.
• Used in material science research for creating specialized polymers or organic electronic materials.
• Intermediate in custom synthesis and contract manufacturing for specialty chemical production.
• Starting material for academic research exploring new organic reactions and catalytic processes.

Basic Information

Product Name	5-(4-Methoxybenzyloxy)-2-Ethynyl-1,3-Difluorobenzene
CAS No.	1432754-28-3
Molecular Formula	C₁₆H₁₂F₂O₂
Molecular Weight	274.26 g/mol
Synonyms	1,3-Difluoro-5-[(4-methoxyphenyl)methoxy]-2-ethynylbenzene; 2-Ethynyl-1,3-difluoro-5-[(4-methoxybenzyl)oxy]benzene; 5-[(4-Methoxybenzyl)oxy]-2-ethynyl-1,3-difluorobenzene; 2-Ethynyl-1,3-difluoro-5-(4-methoxybenzyloxy)benzene; 1,3-Difluoro-5-(4-methoxybenzyloxy)-2-ethynylbenzene; 5-(p-Methoxybenzyloxy)-2-ethynyl-1,3-difluorobenzene
EINECS	Contact for details

Quality Control

Our 5-(4-Methoxybenzyloxy)-2-Ethynyl-1,3-Difluorobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor quality protocols to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.