Description

4,4,5,5-Tetramethyl-2-(4-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Phenyl)-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound matters because it provides a stable, reactive handle for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. Pharmaceutical, agrochemical, and advanced materials researchers need it to efficiently create novel carbon-carbon bonds in the development of active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl scaffolds found in drug candidates.
• Agrochemical Development: Used to synthesize novel active ingredients for crop protection products, leveraging the stability of the pinacol boronate group.
• Material Science & OLED Research: Serves as a building block for creating organic semiconductors, liquid crystals, and light-emitting materials.
• Chemical Biology & Probe Design: Enables the site-specific labeling and functionalization of biomolecules for diagnostic and research applications.
• Polymer Chemistry: Facilitates the synthesis of specialty polymers with tailored properties through controlled coupling reactions.
• Catalyst Ligand Synthesis: Used in the preparation of sophisticated ligand systems for transition metal catalysis.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(4-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Phenyl)-1,3,2-Dioxaborolane
CAS No.	1432571-98-6
Molecular Formula	C₁₆H₂₂BF₃O₂
Molecular Weight	314.15 g/mol
Synonyms	2-[4-(1,1,1-Trifluoro-2-methylpropan-2-yl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(1,1,1-Trifluoro-2-methylpropan-2-yl)phenylboronic acid pinacol ester; 4-(2,2,2-Trifluoro-1,1-dimethylethyl)phenylboronic acid pinacol ester; 4-(1,1,1-Trifluoro-2-methyl-2-propyl)phenylboronic acid pinacol ester; 4-(3,3,3-Trifluoro-2-methyl-2-propyl)phenylboronic acid pinacol ester; 4-(α,α,α-Trifluoro-2-methylisopropyl)phenylboronic acid pinacol ester; (4-(1,1,1-Trifluoro-2-methylpropan-2-yl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(4-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Phenyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B), and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.