Description

2-(2-Cyclopropylethynyl)-4,4,5,5-Tetramethyl-1,3,2-dioxaborolane is a specialized organoboron building block, specifically a pinacol-protected cyclopropylethynyl boronic ester, valued for its role in advanced synthetic chemistry. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures with high fidelity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the cyclopropylethynyl moiety into drug candidates, particularly in the synthesis of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the cyclopropane ring can confer specific biological activity.
• Material Science Research: Employed in the synthesis of conjugated polymers and organic electronic materials for OLEDs or semiconductors.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein functions.
• Academic & Industrial R&D: A versatile reagent for methodological development in cross-coupling and C-H functionalization chemistry.

Basic Information

Product Name	2-(2-Cyclopropylethynyl)-4,4,5,5-Tetramethyl-1,3,2-dioxaborolane
CAS No.	1432491-43-4
Molecular Formula	C₁₃H₁₉BO₂
Molecular Weight	218.10 g/mol
Synonyms	2-(Cyclopropylethynyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Cyclopropylethynyl pinacol boronate; (Cyclopropylethynyl)boronic acid pinacol ester; 2-(2-Cyclopropylethynyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; Cyclopropylethynyl-Bpin; Pinacol (cyclopropylethynyl)boronate; CAS 1432491-43-4
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Cyclopropylethynyl)-4,4,5,5-Tetramethyl-1,3,2-dioxaborolane is manufactured and tested under strict quality management systems to ensure consistency and reliability for critical R&D and scale-up processes. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, typically verified by techniques such as NMR, HPLC, and GC. Our commitment to quality supports compliance with the stringent requirements of pharmaceutical and advanced material development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (NMR)	Conforms to structure (¹H NMR, ¹³C NMR, ¹¹B NMR)
Purity (HPLC/GC)	≥95% (Typical: 97-99%)
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.