Description

Methyl 1-(4-Bromophenyl)-3-Hydroxycyclobutanecarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a functionalized cyclobutane ring system. This compound is valued for its unique structural motif, which is crucial for synthesizing novel active pharmaceutical ingredients (APIs) with potential therapeutic applications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, particularly in medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or metabolic diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its constrained cyclobutane scaffold and modifiable functional groups.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Chemical Biology Probes: Can be utilized to create molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized, high-value compounds.

Basic Information

Product Name	Methyl 1-(4-Bromophenyl)-3-Hydroxycyclobutanecarboxylate
CAS No.	1432059-59-0
Molecular Formula	C12H13BrO3
Molecular Weight	285.14 g/mol
Synonyms	Methyl 1-(4-bromophenyl)-3-hydroxycyclobutanecarboxylate; 3-Hydroxy-1-(4-bromophenyl)cyclobutanecarboxylic acid methyl ester; 1-(4-Bromophenyl)-3-hydroxycyclobutanecarboxylic acid methyl ester; Cyclobutanecarboxylic acid, 1-(4-bromophenyl)-3-hydroxy-, methyl ester; Methyl 3-hydroxy-1-(p-bromophenyl)cyclobutanecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl 1-(4-Bromophenyl)-3-Hydroxycyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with ICH guidelines and customer-specific requirements for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.