Description

Ethyl 3-Chloro-4-Fluoro-5-Nitrobenzoate is a high-purity, multi-functional aromatic ester building block of significant importance in advanced organic synthesis. Its molecular structure, featuring chloro, fluoro, and nitro substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a substituted benzoate core for biological activity.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides, where the halogen and nitro groups contribute to efficacy and stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex dyes and organic pigments due to its nitro-aromatic structure.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) for creating biaryl structures, common in many drug molecules.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	Ethyl 3-Chloro-4-Fluoro-5-Nitrobenzoate
CAS No.	1431505-19-9
Molecular Formula	C9H7ClFNO4
Molecular Weight	247.61 g/mol
Synonyms	Benzoic acid, 3-chloro-4-fluoro-5-nitro-, ethyl ester; Ethyl 3-chloro-4-fluoro-5-nitrobenzoate; 3-Chloro-4-fluoro-5-nitrobenzoic acid ethyl ester; Ethyl 3-chloro-4-fluoro-5-nitrobenzoate (CAS 1431505-19-9); 5-Nitro-3-chloro-4-fluorobenzoic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 3-Chloro-4-Fluoro-5-Nitrobenzoate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.