Description

4-Chloro-3-Fluoro-5-(Trifluoromethyl)Benzylbromide is a high-value, multi-functional halogenated benzyl bromide building block. This compound matters for its unique molecular architecture, which combines chlorine, fluorine, and trifluoromethyl groups to impart significant lipophilicity and metabolic stability, making it a critical intermediate in advanced synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for synthesizing specialty monomers, liquid crystals, and advanced polymers with unique electronic or surface properties.
• Cross-Coupling Reactions: The benzyl bromide moiety is an excellent electrophile for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Fluorine Chemistry: An essential substrate for further fluorination or functionalization studies, leveraging its existing fluorine atoms as directing or stabilizing groups.
• Contract Research & Manufacturing (CRAM): Supplied to custom synthesis and development organizations for client-directed projects requiring this specific halogenated scaffold.

Basic Information

Product Name	4-Chloro-3-Fluoro-5-(Trifluoromethyl)Benzylbromide
CAS No.	1431329-80-4
Molecular Formula	C9H4BrClF4
Molecular Weight	303.48 g/mol
Synonyms	1-(Bromomethyl)-4-chloro-3-fluoro-5-(trifluoromethyl)benzene; (4-Chloro-3-fluoro-5-(trifluoromethyl)phenyl)methyl bromide; α-Bromo-4-chloro-3-fluoro-5-(trifluoromethyl)toluene; 4-Chloro-3-fluoro-5-trifluoromethylbenzyl bromide; 4-Chloro-3-fluoro-α-bromo-alpha,alpha,α-trifluoro-p-xylene; Benzene, 1-(bromomethyl)-4-chloro-3-fluoro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluoro-5-(Trifluoromethyl)Benzylbromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.