Description

1-Adamantylmethyl-5-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, functionalized pyrazole derivative containing a pinacol boronate ester group and a bulky adamantyl moiety, making it a versatile building block for advanced organic synthesis. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex molecular architectures with high precision. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and materials science who require sophisticated intermediates for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, antiviral agents, and enzyme inhibitors.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the adamantyl group for enhanced biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester functionality is specifically designed for efficient palladium-catalyzed coupling with aryl or vinyl halides, enabling rapid library synthesis.
• Chemical Biology Probes: Utilized in the creation of labeled compounds or probes for studying biological pathways and protein interactions.
• Catalyst Ligand Development: The pyrazole and adamantyl structure can be modified to create novel ligands for transition metal catalysis.

Basic Information

Product Name	1-Adamantylmethyl-5-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1430845-70-7
Molecular Formula	C21H33BN2O2
Molecular Weight	356.31 g/mol
Synonyms	4-(1-Adamantylmethyl)-5-methyl-1H-pyrazole-4-boronic acid pinacol ester; 1-(Adamantan-1-ylmethyl)-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Adamantylmethyl-5-methyl-4-(pinacolboron)-1H-pyrazole; ADAMANTYLMETHYL-METHYL-PYRAZOLE-BORONIC ESTER; 1H-Pyrazole, 1-(1-adamantylmethyl)-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1430845-70-7
EINECS	Contact for details

Quality Control

Our 1-Adamantylmethyl-5-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee batch-to-batch consistency and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.