Description

1H-Pyrazole, 1-[(2,5-Difluorophenyl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value boronic ester derivative of a pyrazole scaffold, serving as a critical advanced pharmaceutical intermediate for modern drug discovery. Its molecular architecture, featuring both a difluorophenyl group and a protected boronic acid moiety, makes it an essential building block for constructing complex molecules via Suzuki-Miyaura cross-coupling reactions. This compound is primarily sought by R&D and process chemistry teams in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Essential boron reagent for forming carbon-carbon bonds in medicinal chemistry and material synthesis.
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and insecticides with enhanced properties.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorinated Compound Libraries: Enables the creation of diverse compound libraries for high-throughput screening in drug discovery.
• Material Science: Intermediate for synthesizing organic electronic materials and functional polymers.

Basic Information

Item	Details
Product Name	1H-Pyrazole, 1-[(2,5-Difluorophenyl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1430751-16-8
Molecular Formula	C16H21BF2N2O2
Molecular Weight	322.16 g/mol
Synonyms	1-[(2,5-Difluorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(2,5-Difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 1-(2,5-Difluorobenzyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(2,5-Difluorobenzyl)-4-(pinacolboryl)-1H-pyrazole; 4-(Pinacolboryl)-1-(2,5-difluorobenzyl)pyrazole; 1-(2,5-Difluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1430751-16-8
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole, 1-[(2,5-Difluorophenyl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature is 2-8°C for prolonged shelf life.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.