Description

1-(2-Chlorobenzyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-purity boronic ester derivative, a crucial intermediate in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its pyrazole core for biological activity.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as OLEDs and semiconductors, due to its conjugated structure.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura couplings to form carbon-carbon bonds, facilitating the construction of biaryl and heterobiaryl structures.
• Chemical Biology Probes: Utilized in the development of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs serving the life sciences sector.

Basic Information

Product Name	1-(2-Chlorobenzyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1430750-66-5
Molecular Formula	C16H22BClN2O2
Molecular Weight	320.62 g/mol
Synonyms	1-(2-Chlorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(2-Chlorobenzyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole, 1-[(2-chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2-chlorobenzyl)pyrazole; 1-(2-Chlorobenzyl)-4-(pinacolboron)pyrazole; 1-(2-Chlorobenzyl)-4-BPin-pyrazole; 1-(2-Chlorobenzyl)-4-(pinacolatoboron)-1H-pyrazole; CAS 1430750-66-5
EINECS	Contact for details

Quality Control

Our 1-(2-Chlorobenzyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.