Description

1H-Pyrazole, 1-[(4-Chlorophenyl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients. The compound is supplied under strict quality control to ensure batch-to-batch consistency and optimal performance in sensitive applications.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the pyrazole core for biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the development of chemical probes and inhibitors.
• Catalyst Ligand Development: The pyrazole-boronate structure can be utilized to develop novel ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Item	Details
Product Name	1H-Pyrazole, 1-[(4-Chlorophenyl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1430750-51-8
Molecular Formula	C16H22BClN2O2
Molecular Weight	320.62 g/mol
Synonyms	1-[(4-Chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(4-chlorobenzyl)-1H-pyrazole; 1-(4-Chlorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 1-(4-Chlorobenzyl)-1H-pyrazole-4-boronic acid pinacol ester; (1-(4-Chlorobenzyl)-1H-pyrazol-4-yl)boronic acid pinacol ester; CAS 1430750-51-8
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole, 1-[(4-Chlorophenyl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and LC-MS, to ensure identity, purity, and conformity to client specifications. Certificates of Analysis (COA) documenting all critical quality attributes are provided and available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.