Description

2,2-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chroman-4-one is a high-value, synthetically versatile boronic ester derivative of chroman-4-one. This compound serves as a critical advanced pharmaceutical intermediate (API) and a key building block in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions. It is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to construct complex molecular architectures with high precision.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection products.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLEDs and semiconductors.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group enables efficient carbon-carbon bond formation with aryl/vinyl halides under palladium catalysis.
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors for biochemical research.
• Ligand and Catalyst Development: Acts as a precursor for creating novel ligands and catalysts in asymmetric synthesis.

Basic Information

Product Name	2,2-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chroman-4-one
CAS No.	1430472-51-7
Molecular Formula	C₁₉H₂₇BO₄
Molecular Weight	330.23 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2-dimethylchroman-4-one; 2,2-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-chromanone; 2,2-Dimethyl-6-(pinacolatoboryl)chroman-4-one; 6-(Pinacolatoboryl)-2,2-dimethylchroman-4-one; Chroman-4-one, 2,2-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1430472-51-7; Boronic acid, B-(2,2-dimethyl-4-oxo-4H-1-benzopyran-6-yl)-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2,2-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chroman-4-one is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H and ¹³C), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged operations to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.