Description

4,6-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is a high-purity, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is critically needed by R&D and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, enabling the introduction of the pyrimidine pharmacophore.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and components for organic semiconductors.
• Chemical Biology & Drug Discovery: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and the synthesis of compound libraries for high-throughput screening.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds between the pyrimidine ring and various aryl or heteroaryl halides.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing novel bidentate or polydentate ligands used in homogeneous catalysis.

Basic Information

Product Name	4,6-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine
CAS No.	1430233-43-4
Molecular Formula	C12H19BN2O2
Molecular Weight	234.11 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4,6-dimethylpyrimidine; 4,6-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 4,6-Dimethylpyrimidin-5-ylboronic acid pinacol ester; 5-Pyrimidineboronic acid, 4,6-dimethyl-, 1,1,1',1'-tetramethyl-1,1'-spirobi[1,3,2]dioxaborolan-2-yl ester; 4,6-Dimethyl-5-pyrimidineboronic acid pinacol ester; 5-Boronic acid pinacol ester-4,6-dimethylpyrimidine
EINECS	Contact for details

Quality Control

Our 4,6-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistent performance in cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every lot and provided upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term stability, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.