Description

1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-2-One is a high-value pharmaceutical intermediate and versatile building block in organic synthesis, specifically designed for advanced cross-coupling reactions. Its core value lies in the pinacol boronate ester functional group, which enables efficient and selective Suzuki-Miyaura couplings, a cornerstone of modern medicinal chemistry. This compound is essential for researchers and manufacturers in pharmaceutical R&D and fine chemical synthesis who require reliable, high-purity precursors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex indolinone scaffolds.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical boron-containing coupling partner for forming carbon-carbon bonds between aromatic and heteroaromatic systems under mild conditions.
• Medicinal Chemistry Research: Used in the discovery and optimization of new chemical entities for various therapeutic areas, including oncology and central nervous system (CNS) disorders.
• Ligand and Material Science: Employed in the development of novel organic ligands for catalysis and as a precursor for advanced organic electronic materials.
• Process Chemistry & Scale-Up: Supplied in development and commercial quantities to support the transition from laboratory-scale research to industrial manufacturing.

Basic Information

Product Name	1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-2-One
CAS No.	1428666-17-4
Molecular Formula	C15H20BNO3
Molecular Weight	273.14 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methylindolin-2-one; 1-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-indolinone; 2-Oxo-1-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline; 1-Methyl-6-(pinacolatoboryl)indolin-2-one; 6-Borono-1-methylindolin-2-one pinacol ester; 1-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-2H-indol-2-one; CAS 1428666-17-4
EINECS	Contact for details

Quality Control

Our 1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-2-One is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.