Description

n-(4-Methoxybenzyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, making it a critical building block for modern synthetic chemistry. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for creating complex biaryl structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking reliable, high-quality boronic acid derivatives for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or heterobiaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between its boronate ester and various organic halides, crucial for constructing complex molecular architectures.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Can be employed as a tagging or labeling reagent due to its reactive boronate handle for bioconjugation strategies.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries via parallel synthesis for high-throughput screening.

Basic Information

Product Name	n-(4-Methoxybenzyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1428336-01-9
Molecular Formula	C19H25BN2O3
Molecular Weight	340.23 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[(4-methoxyphenyl)methyl]pyridin-2-amine; 2-Pyridinamine, N-[(4-methoxyphenyl)methyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; N-(4-Methoxybenzyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; 5-(Pinacolatoboryl)-N-(4-methoxybenzyl)pyridin-2-amine; CAS 1428336-01-9
EINECS	Contact for details

Quality Control

Every batch of n-(4-Methoxybenzyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical intermediate grade meets stringent in-house specifications, with purity typically exceeding 97% (by HPLC). Certificates of Analysis (COA) detailing batch-specific results from NMR, HPLC, and mass spectrometry are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.