Description

8-Chloro-1-Methyl-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-3,4-Dihydro-1H-Quinolin-2-One is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly in drug discovery programs targeting a range of therapeutic areas.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for constructing carbon-carbon bonds in complex organic synthesis.
• Pharmaceutical Intermediate: Used in the research and development of new active pharmaceutical ingredients (APIs), particularly for oncology, CNS, and anti-infective drug candidates.
• Agrochemical Synthesis: Employed as a building block in the development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Utilized in the synthesis of organic electronic materials and functional polymers.
• Chemical Biology Probes: Acts as a precursor for creating labeled compounds and probes used in biochemical assays and diagnostic research.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial manufacturing of fine chemicals.

Basic Information

Item	Details
Product Name	8-Chloro-1-Methyl-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-3,4-Dihydro-1H-Quinolin-2-One
CAS No.	1427588-44-0
Molecular Formula	C16H21BClNO3
Molecular Weight	321.60 g/mol
Synonyms	8-Chloro-1-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroquinolin-2(1H)-one; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-8-chloro-1-methyl-3,4-dihydro-2(1H)-quinolinone; 8-Chloro-1-methyl-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroquinolin-2-one; 1427588-44-0; Boronic acid, B-(8-chloro-1-methyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl)-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 8-Chloro-1-Methyl-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-3,4-Dihydro-1H-Quinolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by NMR)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.