Description

2-Bromo-3'-Fluoro-2'-Methoxyacetophenone, also known as 2-Bromo-1-(3-Fluoro-2-Methoxyphenyl)Ethan-1-One or 2-(Bromoacetyl)-6-Fluoroanisole, is a high-value, multi-functional organic building block. This compound is a critical intermediate in modern synthetic chemistry, prized for its reactive bromoacetyl group and strategically placed fluorine and methoxy substituents. It is primarily sought after by research institutions and pharmaceutical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS) or possessing anti-inflammatory properties.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as an affinity label or a reactive handle for modifying proteins and studying enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing client-specific compounds.
• Academic & R&D Laboratories: Utilized in methodological development and exploratory chemistry for creating novel heterocyclic compounds and complex molecular architectures.

Basic Information

Product Name	2-Bromo-3'-Fluoro-2'-Methoxyacetophenone
CAS No.	1427403-76-6
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	2-Bromo-1-(3-fluoro-2-methoxyphenyl)ethan-1-one; 2-(Bromoacetyl)-6-fluoroanisole; 1-(3-Fluoro-2-methoxyphenyl)-2-bromoethanone; 2-Bromo-1-(3-fluoro-2-methoxyphenyl)ethanone; 6-Fluoro-2-methoxy-α-bromoacetophenone; α-Bromo-3'-fluoro-2'-methoxyacetophenone; 2-Bromo-3'-fluoro-2'-methoxyacetophenone
EINECS	Contact for details

Quality Control

Our 2-Bromo-3'-Fluoro-2'-Methoxyacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.