Description

2-Bromo-3'-Chloro-5'-Fluoroacetophenone is a high-purity, multi-halogenated acetophenone derivative serving as a critical building block in advanced organic synthesis. Its precise halogen substitution pattern makes it an invaluable intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research and development chemists and process scale-up teams in fine chemical manufacturing who require reliable, high-quality intermediates for API synthesis and material science applications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing halogenated aromatic systems for targeted biological activity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the bromo, chloro, and fluoro substituents contribute to product efficacy and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Utilized in organometallic chemistry for creating novel ligands and catalysts used in cross-coupling and other catalytic reactions.
• Chemical Biology Probes: Acts as a starting material for synthesizing fluorescent tags or molecular probes for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A fundamental substrate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Bromo-3'-Chloro-5'-Fluoroacetophenone
CAS No.	1427375-70-9
Molecular Formula	C8H5BrClFO
Molecular Weight	251.48 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-2-bromoethanone; 2-Bromo-1-(3-chloro-5-fluorophenyl)ethan-1-one; α-Bromo-3-chloro-5-fluoroacetophenone; 3'-Chloro-5'-fluoro-2-bromoacetophenone; 2-Bromo-3-chloro-5-fluoroacetophenone; Ethanone, 2-bromo-1-(3-chloro-5-fluorophenyl)-; Bromo(3-chloro-5-fluorophenyl)methanone (common name variant)
EINECS	Contact for details

Quality Control

Our 2-Bromo-3'-Chloro-5'-Fluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.