Description

[3,5-Dimethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrazol-1-Yl]-Acetic Acid tert-Butyl Ester is a high-value, protected boronic ester derivative that serves as a critical synthetic intermediate. Its primary commercial value lies in enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce functionalized pyrazole scaffolds into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing pyrazole heterocycles, which are prevalent in drugs targeting inflammation, metabolic disorders, and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that leverage the pyrazole moiety for biological activity.
• Material Science Research: Serves as a precursor for creating functional organic materials, such as ligands for catalysts or monomers for specialty polymers.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of lead compounds through structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for the development and scale-up of client-specific molecular entities.
• Academic Research: A valuable reagent for methodology development and complex molecule synthesis in university and institutional laboratories.

Basic Information

Product Name	[3,5-Dimethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrazol-1-Yl]-Acetic Acid tert-Butyl Ester
CAS No.	1426671-41-1
Molecular Formula	C₁₇H₂₉BN₂O₄
Molecular Weight	336.24 g/mol
Synonyms	tert-Butyl [3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate; 1H-Pyrazole-1-acetic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5-dimethyl-, 1,1-dimethylethyl ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5-dimethyl-1H-pyrazole-1-acetic acid tert-butyl ester; 3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetic acid tert-butyl ester; Boronic acid, B-[1-[(1,1-dimethylethoxy)carbonyl]methyl]-3,5-dimethyl-1H-pyrazol-4-yl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our [3,5-Dimethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrazol-1-Yl]-Acetic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.