Description

4,4,5,5-Tetramethyl-2-(4-[4-(Trifluoromethoxy)Phenoxy]Phenyl)-1,3,2-Dioxaborolane is a high-purity, advanced pharmaceutical intermediate and key building block in organic synthesis. This compound matters for its critical role in facilitating Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific aromatic architectures.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds under mild conditions.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Acts as a synthetic handle for labeling and modifying biomolecules in drug discovery and diagnostic tool development.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(4-[4-(Trifluoromethoxy)Phenoxy]Phenyl)-1,3,2-Dioxaborolane
CAS No.	1426337-32-7
Molecular Formula	C19H20BF3O4
Molecular Weight	380.17 g/mol
Synonyms	2-[4-[4-(Trifluoromethoxy)phenoxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(4-(Trifluoromethoxy)phenoxy)phenylboronic acid pinacol ester; [4-[4-(Trifluoromethoxy)phenoxy]phenyl]boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1,3,2-dioxaborolane; (4-(4-(Trifluoromethoxy)phenoxy)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(4-[4-(Trifluoromethoxy)Phenoxy]Phenyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every lot and provided upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.