Description

5,5-Difluorotetrahydro-2H-Pyran-2-Carboxylic Acid is a high-value fluorinated heterocyclic building block, distinguished by its difluorinated pyran ring and carboxylic acid functionality. This compound is critical for introducing conformational rigidity and enhancing metabolic stability in advanced pharmaceutical and agrochemical intermediates. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorine atoms to modulate lipophilicity and bioavailability.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the difluoropyran moiety can improve environmental stability and efficacy.
• Material Science Precursor: Serves as a monomer or functionalizing agent for developing specialty polymers with unique surface properties or fluorine-containing coatings.
• Ligand and Catalyst Development: Employed in organometallic chemistry for constructing complex, fluorinated ligands that can influence catalytic activity and selectivity.
• Fluorine Chemistry Research: An essential building block in academic and industrial laboratories exploring new C-F bond formation reactions and fluorinated molecular architectures.
• Diagnostic Agent Development: Potential use in synthesizing fluorinated contrast agents or probes for imaging technologies like PET (Positron Emission Tomography).

Basic Information

Product Name	5,5-Difluorotetrahydro-2H-Pyran-2-Carboxylic Acid
CAS No.	1426135-66-1
Molecular Formula	C6H6F2O3
Molecular Weight	164.11 g/mol
Synonyms	5,5-Difluorotetrahydro-2H-pyran-2-carboxylic acid; 2H-Pyran-2-carboxylic acid, 5,5-difluorotetrahydro-; 5,5-Difluorotetrahydropyran-2-carboxylic Acid; 5,5-Difluorooxane-2-carboxylic Acid; 2-Carboxy-5,5-difluorotetrahydropyran; Difluoropyrancarboxylic Acid; CAS 1426135-66-1
EINECS	Contact for details

Quality Control

Our 5,5-Difluorotetrahydro-2H-Pyran-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.