Description

tert-Butyl 4-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl)Piperidine-1-Carboxylate is a high-value, protected piperidine boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is critically needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules. Its protected amine and stable boronate ester functionalities offer superior handling and reactivity control in multi-step syntheses.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in creating complex amine-containing heterocycles.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds with aryl or vinyl halides, a cornerstone reaction in medicinal chemistry.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides that require specific piperidine-based architectures.
• Ligand and Catalyst Development: Employed in the synthesis of novel nitrogen-containing ligands for metal catalysts used in asymmetric synthesis and polymerization.
• Material Science: A precursor for creating functionalized polymers or organic electronic materials with tailored properties.
• Chemical Biology & Proteomics: Useful for synthesizing molecular probes and affinity tags for studying biological systems.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening campaigns.

Basic Information

Product Name	tert-Butyl 4-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl)Piperidine-1-Carboxylate
CAS No.	1425335-44-9
Molecular Formula	C17H32BNO4
Molecular Weight	325.26 g/mol
Synonyms	1-Boc-4-((4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)piperidine; 4-((4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]piperidine; N-Boc-4-(pinacolborylmethyl)piperidine; 4-(Pinacolboranylmethyl)-1-N-Boc-piperidine; 4-(Pinacolboronmethyl)-1-Boc-piperidine
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl)Piperidine-1-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and MS, to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with REACH and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.