Description

tert-Butyl (4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Methylcarbamate is a high-value, protected amine-containing boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecular architectures through reliable cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those containing pyridine and amine functionalities.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the boronate ester group facilitates the introduction of complex heterocyclic systems.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and functional polymers requiring specific nitrogen and boron coordination sites.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes and inhibitors targeting specific enzymes or biological pathways.
• Process Chemistry & Scale-up: A reliable intermediate for the kilogram-scale production of target molecules under GMP or non-GMP conditions, owing to its stability and predictable reactivity.

Basic Information

Product Name	tert-Butyl (4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Methylcarbamate
CAS No.	1425334-54-8
Molecular Formula	C18H29BN2O4
Molecular Weight	348.25 g/mol
Synonyms	2-[[(tert-Butoxycarbonyl)amino]methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; N-Boc-2-(Aminomethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; tert-Butyl N-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]methyl]carbamate; 4-Pinacolatoboron-2-N-Boc-aminomethylpyridine; Boc-2-Aminomethyl-4-pyridylboronic acid pinacol ester; (4-(N-Boc-aminomethyl)pyridin-2-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Methylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry, inert atmosphere to minimize exposure to moisture and oxygen, which can affect the stability of the boronic ester and carbamate functional groups.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.