Description

1,3-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2(1H)-One is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for oncology, CNS, and antiviral therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those containing complex pyridone or biaryl motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron-containing coupling partner for the formation of carbon-carbon bonds under mild conditions.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space.
• Process Chemistry Development: Employed in the scale-up and route scouting for the commercial manufacturing of target molecules.
• Agrochemical Synthesis: Potential intermediate in the development of new herbicides or fungicides with specific activity profiles.
• Material Science Precursor: Can be utilized in the synthesis of organic electronic materials or metal-organic frameworks (MOFs).

Basic Information

Product Name	1,3-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2(1H)-One
CAS No.	1425045-01-7
Molecular Formula	C13H20BNO3
Molecular Weight	249.12 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dimethyl-1,2-dihydropyridin-2-one; 1,3-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyridin-2-one; 2(1H)-Pyridinone, 1,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1,3-Dimethyl-5-(pinacolatoboron)pyridin-2(1H)-one; 5-Pinacolatoborono-1,3-dimethylpyridin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 1,3-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2(1H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliable consistency and traceability for your research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.