Description

2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide (Wx191838) is a high-purity, advanced pharmaceutical intermediate and building block featuring a benzamide core with a methoxy substituent and a key pinacol boronate ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS research.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group serves as a versatile handle for forming carbon-carbon bonds with aryl/heteroaryl halides under palladium catalysis.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific benzamide-based structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Chemical Biology & Proteomics: Can be utilized as a precursor for bioconjugation reagents or probes targeting specific biological pathways.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects requiring precise functionalization of the benzamide scaffold.

Basic Information

Product Name	2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide (Wx191838)
CAS No.	1424432-41-6
Molecular Formula	C14H20BNO4
Molecular Weight	277.13 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxybenzamide; 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; WX-191838; Wx191838; Benzamide, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-Methoxy-5-(pinacolatoboron)benzamide; 5-(Pinacolatoboran-2-yl)-2-methoxybenzamide
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.