Description

Methyl 1-[2-Chloro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a cyclopropane carboxylate ester and a protected boronic acid moiety. This compound is essential for facilitating efficient cross-coupling reactions, particularly in the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester building block for constructing biaryl and heterobiaryl structures in medicinal chemistry.
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, including potential kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Employed in the creation of advanced active ingredients for crop protection products.
• Material Science Research: Acts as a precursor for organic electronic materials and liquid crystals due to its rigid cyclopropane core and functional handles.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Process Chemistry & Scale-Up: Provides a stable, storable alternative to sensitive boronic acids for large-scale manufacturing processes.

Basic Information

Product Name	Methyl 1-[2-Chloro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carboxylate
CAS No.	1423706-80-2
Molecular Formula	C17H22BClO4
Molecular Weight	344.62 g/mol
Synonyms	Methyl 1-[2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarboxylate; 2-Chloro-4-(1-Methoxycarbonylcyclopropyl)phenylboronic Acid Pinacol Ester; (2-Chloro-4-(1-(Methoxycarbonyl)cyclopropyl)phenyl)boronic Acid Pinacol Ester; Methyl 1-(2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylate; BCPE Ester Derivative; Cyclopropanecarboxylic Acid, 1-[2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 1-[2-Chloro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.