Description

Methyl 1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl]cyclobutane-1-carboxylate is a high-value, synthetically versatile boronic ester derivative. This compound is a critical advanced pharmaceutical intermediate (API) and a key building block in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions. It is essential for research and development chemists in the pharmaceutical, agrochemical, and materials science industries who require precise, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for drug discovery and development programs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds, enabling the construction of biaryl and other complex organic frameworks.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Employed in the creation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Materials Science Research: A building block for the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and target identification.

Basic Information

Item	Information
Product Name	Methyl 1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl]cyclobutane-1-carboxylate
CAS No.	1423704-86-2
Molecular Formula	C18H25BO4
Molecular Weight	316.20 g/mol
Synonyms	Methyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanecarboxylate; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanecarboxylic acid methyl ester; Cyclobutanecarboxylic acid, 1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, methyl ester; 1423704-86-2; Methyl 1-(4-(pinacolatoboryl)phenyl)cyclobutanecarboxylate; 1-(4-Pinacolatoborylphenyl)cyclobutanecarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl]cyclobutane-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and high-purity research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the original container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.