Description

1-[4-(4.4.5.5-Tetramethyl-[1.3.2]Dioxaborolan-2-Yl)-Biphenyl-4-Yl]-Cyclopropanecarboxylic Acid Methyl Ester is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling efficient cross-coupling reactions, particularly in the synthesis of complex, biologically active molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron-containing coupling partner for the synthesis of biaryl and heterobiaryl structures, a cornerstone in modern medicinal chemistry.
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, including potential therapies for oncology, CNS disorders, and inflammatory diseases.
• Agrochemical Synthesis: Employed in creating advanced active ingredients for crop protection products, leveraging its ability to introduce complex aromatic systems.
• Material Science Research: Acts as a building block for the synthesis of organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	1-[4-(4.4.5.5-Tetramethyl-[1.3.2]Dioxaborolan-2-Yl)-Biphenyl-4-Yl]-Cyclopropanecarboxylic Acid Methyl Ester
CAS No.	1423700-75-7
Molecular Formula	C23H27BO4
Molecular Weight	378.27 g/mol
Synonyms	[4'-(Methoxycarbonylcyclopropyl)[1,1'-biphenyl]-4-yl]boronic acid pinacol ester; Methyl 1-[4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1'-biphenyl]-4-yl]cyclopropanecarboxylate; 1-[4'-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-4-yl]cyclopropanecarboxylic acid methyl ester; Biphenyl-4-boronic acid, 4'-(methoxycarbonylcyclopropyl)-, pinacol ester; 4'-(Methoxycarbonylcyclopropyl)biphenyl-4-boronic acid pinacol ester; CAS 1423700-75-7
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and LC-MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.