Description

2-(4-(1-Bromoethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a brominated phenylboronic ester, essential for advanced synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the synthesis of novel active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates through palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring complex biphenyl structures.
• Material Science Research: Enables the creation of organic electronic materials, such as polymers and small molecules for OLEDs and semiconductors.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A critical reagent for fine chemical and custom synthesis houses serving the life sciences sector.

Basic Information

Item	Detail
Product Name	2-(4-(1-Bromoethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1422655-36-4
Molecular Formula	C14H20BBrO2
Molecular Weight	311.02 g/mol
Synonyms	1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl bromide; 2-[4-(1-Bromoethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(1-Bromoethyl)phenylboronic acid pinacol ester; (4-(1-Bromoethyl)phenyl)boronic acid pinacol ester; 1-Bromo-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethane
EINECS	Contact for details

Quality Control

Every batch of our 2-(4-(1-Bromoethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive cross-coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality management system supports cGMP and ISO standards for traceability and consistency, making this material suitable for research through to pre-clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.