Description

2-(Cyclobutylmethyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity organoboron reagent, specifically a pinacol boronic ester, valued for its stability and reactivity in advanced synthetic transformations. This compound is essential for facilitating key carbon-carbon bond-forming reactions, enabling the efficient construction of complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications in medicinal chemistry and functional material synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A critical reagent for forming biaryl and other C-C bonds in pharmaceutical intermediate synthesis.
• Medicinal Chemistry & Drug Discovery: Used to introduce the cyclobutylmethyl moiety into lead compounds for structure-activity relationship (SAR) studies and library synthesis.
• Agrochemical Intermediate Synthesis: Employed in the creation of novel active ingredients with specific steric and electronic properties.
• Functional Material Development: Serves as a building block for organic electronic materials, such as those used in OLEDs and semiconductors.
• Process Chemistry & Scale-up: Provides a reliable and stable boronate source for optimizing large-scale manufacturing routes.
• Academic & Industrial R&D: A versatile tool for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	2-(Cyclobutylmethyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1422558-28-8
Molecular Formula	C11H21BO2
Molecular Weight	196.10 g/mol
Synonyms	Cyclobutylmethylboronic acid pinacol ester; (2-(Cyclobutylmethyl)-1,3,2-dioxaborolan-4,4,5,5-tetramethyl); Cyclobutylmethyl-Bpin; Pinacol (cyclobutylmethyl)boronate; Cyclobutylmethylboronate pinacol ester; B-(Cyclobutylmethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Cyclobutylmethylboronic acid, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(Cyclobutylmethyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.