Description

1-[2-(Azetidin-1-Yl)Ethyl]-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-purity, advanced pharmaceutical intermediate featuring a pyrazole core functionalized with both an azetidine and a protected boronic ester group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing carbon-carbon bonds. It is an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for targeted therapies and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those requiring the incorporation of a boronic acid/ester functionality for coupling.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to introduce the pyrazole-azetidine moiety into larger molecular architectures, enabling the rapid exploration of chemical space in drug discovery.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing libraries of compounds for high-throughput screening against various biological targets.
• Agrochemical Synthesis: Employed in the development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Ligand and Catalyst Development: Can be utilized in the design of novel ligands for catalysis or as part of organometallic complexes.
• Chemical Biology Probes: Useful for creating tagged molecules to study biological processes and protein interactions.

Basic Information

Item	Detail
Product Name	1-[2-(Azetidin-1-Yl)Ethyl]-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1422126-12-2
Molecular Formula	C14H26BN3O2
Molecular Weight	279.19 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[2-(azetidin-1-yl)ethyl]-1H-pyrazole; 1H-Pyrazole, 1-[2-(azetidin-1-yl)ethyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-(2-(Azetidin-1-yl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; Azetidine-pyrazole boronic ester; Pyrazole boronic ester pinacol ester; Borylation Reagent 1422126-12-2
EINECS	Contact for details

Quality Control

Our 1-[2-(Azetidin-1-Yl)Ethyl]-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.