Description

2-(3-Chloro-5-Fluoro-4-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity boronic ester derivative, serving as a critical advanced pharmaceutical intermediate in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl scaffolds. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific halogenated biaryl structures.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular architecture is crucial.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds and molecular probes used in drug discovery and diagnostic assay development.
• Catalyst Ligand Precursor: Can be utilized to synthesize novel ligand systems for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and custom synthesis houses serving the life sciences sector.

Basic Information

Item	Details
Product Name	2-(3-Chloro-5-Fluoro-4-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1422022-15-8
Molecular Formula	C13H17BClFO3
Molecular Weight	285.53 g/mol
Synonyms	3-Chloro-5-fluoro-4-methoxyphenylboronic acid pinacol ester; (3-Chloro-5-fluoro-4-methoxyphenyl)boronic acid pinacol ester; 3-Chloro-5-fluoro-4-methoxybenzeneboronic acid pinacol ester; 2-(3-Chloro-5-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (3-chloro-5-fluoro-4-methoxyphenyl)boronate; 3-Chloro-5-fluoro-4-methoxy phenylboronic acid pinacol ester; 3-Chloro-5-fluoro-4-methoxybenzeneboronic acid, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(3-Chloro-5-Fluoro-4-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.