Description

3-Methylisoxazole-4-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound is a protected boronic acid derivative, offering enhanced stability and handling characteristics for critical coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic molecules and active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aromatic and heteroaromatic systems, enabling the construction of complex molecular scaffolds.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, particularly those containing the isoxazole pharmacophore.
• Agrochemical Active Ingredient Development: Employed in creating advanced herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Serves as a precursor for synthesizing organic electronic materials and functional polymers.
• Chemical Biology & Probe Development: Utilized to create tagged molecules for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: The pinacol ester protection offers superior stability for handling in multi-step synthesis and kilogram-scale manufacturing.

Basic Information

Product Name	3-Methylisoxazole-4-Boronic Acid Pinacol Ester
CAS No.	1421846-79-8
Molecular Formula	C₁₀H₁₆BNO₃
Molecular Weight	209.05 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(3-methylisoxazol-4-yl)-1,3,2-dioxaborolane; 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole; 3-Methylisoxazole-4-boronic acid pinacol ester; Pinacol 3-Methylisoxazole-4-boronate; 3-Methyl-4-isoxazolylboronic acid pinacol ester; 3-Methyl-4-boronoisoxazole pinacol ester; 3-Methyl-4-(pinacolatoboryl)isoxazole
EINECS	Contact for details

Quality Control

Every batch of 3-Methylisoxazole-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and consistency to meet the rigorous demands of research and process chemistry. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.