Description

6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1-Benzopyran-4-One is a high-value, advanced pharmaceutical intermediate and organic building block featuring a protected boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and materials science. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) for drug discovery and development programs.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boronic ester reagent for forming carbon-carbon bonds in the construction of complex biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides requiring specific benzopyran-based scaffolds.
• Material Science: Intermediate in the creation of organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Synthesis: Versatile precursor for further functionalization to create libraries of compounds for high-throughput screening.
• Academic & Contract Research: Essential reagent for methodological development and synthetic chemistry research in academic and CRO laboratories.

Basic Information

Product Name	6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1-Benzopyran-4-One
CAS No.	1421659-47-3
Molecular Formula	C15H19BO4
Molecular Weight	274.12 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-4H-chromen-4-one; 6-(Tetramethyl-1,3,2-dioxaborolan-2-yl)chroman-4-one; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-chromanone; 6-Tetramethyl-1,3,2-dioxaborolan-2-yl-2,3-dihydro-1-benzopyran-4-one; 6-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-chromen-4-one; 6-TMDC; Chroman-4-one, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1-Benzopyran-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) with full characterization data are provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term preservation to maintain optimal reactivity and purity. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.