Description

3-Methyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3H-quinazolin-4-one is a high-value, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex drug candidates. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for the development of new therapeutic agents, particularly in oncology and CNS research. Its specific structure makes it a versatile synthon for constructing novel quinazolinone-based libraries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing the quinazolinone pharmacophore.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group serves as a crucial handle for palladium-catalyzed coupling with aryl/heteroaryl halides, enabling rapid diversification of molecular scaffolds.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and lead optimization programs to explore structure-activity relationships (SAR) and develop novel small-molecule therapeutics.
• Chemical Biology Research: Employed in the synthesis of chemical probes and tool compounds for studying biological pathways and target validation.
• Process Development & Scale-Up: Serves as a starting material for the development of robust, scalable synthetic routes under current Good Manufacturing Practice (cGMP) guidelines.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical market.

Basic Information

Product Name	3-Methyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3H-quinazolin-4-one
CAS No.	1421341-05-0
Molecular Formula	C₁₅H₁₉BN₂O₃
Molecular Weight	286.14 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylquinazolin-4(3H)-one; 3-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4(3H)-quinazolinone; 3-Methyl-7-(pinacolatoboryl)quinazolin-4(3H)-one; 7-BPin-3-methylquinazolin-4-one; Quinazolin-4-one, 3-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-; 1421341-05-0; 3-Methyl-7-(tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-quinazolin-4-one
EINECS	Contact for details

Quality Control

Our 3-Methyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3H-quinazolin-4-one is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.